Oranvate cream is used in short courses to treat severe inflammatory skin disorders, such as those below, when milder corticosteroids have not been effective.Skin disorder called lichen planus, in which there are patches on the skin that appear as flat-topped, shiny, almost violet itchy areas. Skin disorder called discoid lupus erythematosus, which is caused by the immune system attacking the skin.COMPOSITION Oranvate cream contain 100g: Clobetasol propionate 0.050g Excipients: Propylen glycol, Titanium dioxide, Carbomer, Purified water q.s.Corticosteroids (also known as steroids) are medicines used for reducing inflammation. Skin inflammation may occur as a result of an allergic reaction, or irritation of the skin. It is caused by the immune system releasing substances that make blood vessels in the skin widen. This makes the irritated area become red, swollen, itchy and painful, as is seen in dermatitis or eczema.When clobetasol is applied to the skin it works by acting inside the skin cells to decrease the release of these inflammatory substances. This reduces swelling, redness and itch.There is a range of potencies of corticosteroids applied to the skin. Clobetasol propionate is classed as a very potent corticosteroid. It is prescribed to treat severe inflammatory skin disorders such as eczema and psoriasis that have not responded to weaker corticosteroids.Oranvate cream is more greasy than the cream. It is more suitable for very dry, scaly areas of skin, whereas moist or weepy skin is best treated with the cream.INDICATIONS AND USAGE:-Clobetasol propionate cream is a super - high potency corticosteroid Formulation indicated for the relief of the inflammatory and pruritic manifestation of corticosteroid-responsive dermatoses.treatment beyond 2 consecutive weeks is notrecommende, and the total dosage should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic- pituitary-adrenal (HPA)axis.Use in children under 12 years of age is not recommended. As with other highly active corticosteroid, therapy should be discontinued when control has been achieve. If no imprisonment is seen within 2 weeks,reassessment of the diagnosis may be necessary CONTRAINDICATION - Clobetasol propionate cream is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.PRECAUTIONS:-Clobetasol propionate is a topical corticosteroid that has been shown to suppress the HPA axis at doses as low as 2 g per day.Oranvate Cream should not be used in the treatment of rosacea or perioral dermatitis, and should not be used on the face,groin, or axillae.PEDIATRIC USE - Safety and effectiveness of lemonvate cream in children and infants have not been established; therefore, use in Children under 12 years of age is not recommended.Because of a higher ratio of skin surface area to body mass, children are at a greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids. They are therefore also at greater risk of glucocorticosteroid insufficiency after withdrawal of treatment and of cushing Syndrome while on treatment. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children.ADVERSE REACTIONS:- in a controlled trial with lemovite cream the only reported adverse reaction that was considered to be drug related was a report of burning sensation (1.8% of treated patient.) In larger controlled clinical trials with other clobetasol propionate Formulations.the most frequently reported adverse reaction have included skin atrophy,and telangiectasia. Cushing syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulatio. The following additional local adverse reactions are reported infrequently with topical corticosteroids but may occur more frequently with Super high potency corticosteroids such as clobetasol propionate cream . These reaction are listed in approximate decreasing order of occurrence dryness,hypertrichosis , acneiform eruptions.hypopigmentation, perioral dermatitis, allergic contact dermatitis,secondary infraction,striae, and miliaria.OVERDOSAGE- Following topically applied lemonvate cream, clobetasol propionate can be absorbed in sufficient amounts to produce systemic effectsDOSAGE AND ADMINISTRATION- Apply a thin layer of lemonvate cream to the affected area twice daily, or according the physician prescription and rub in gently and completely the active ingredient of lemonvate cream clobetasol propionate, is a super High Potency topical corticosteroid. Therefore Treatment should be limited to 2 consecutive weeks and amounts greater than 50g per week should not be used. Lemonvate cream should not be used with occlusive dressingWarning and how to use(1) This cream is only suitable for body.(2) Keep away from the reach of children.(3) Prohibit the use of this cream in pride.(4) Use up to 90 grams to get the full result.This cream will give results within 4 to 7 days, and if you use this cream on any single side of your body you will get more benefits such as hand and throat face underarm where you like.When using this cream, you can use sunblock cream to use this cream only at night and sunblocks will be used in daylight.This cream containing can be used for 90 grams and it is useful for up to 60 days from the time of opening this cream.Please use this cream for kids over 12 years.For more details contact our customer care and do not forget to comment and advise on our special cosmetic specialists.Thank you and hope you will be with us.